Alcohol Withdrawal Syndrome: Benzodiazepines and Beyond
Alcohol affects the area of the brain responsible for the ‘fight or flight’ function which helps our brains respond to danger, by preparing us to either react or run away. Because alcohol is a depressant, drinking suppresses the ‘fight or flight’ response in your brain and nervous system. For some people, insomnia caused by stopping drinking can be challenging. It’s really important to resist any urge to start drinking again ‘to help get off to sleep’.
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Lorazepam is more suitable in patients with hepatic disease, in the elderly where there is risk of over sedation and respiratory depression with diazepam. Initial doses of 10 mg equivalents of diazepam are given intravenously/intramuscularly and can be repeated every minutes 51,77. Some experts even advice and advocate use of loading doses of diazepam for management of DT. However, it is purely based on clinical experience as no clinical trials have been conducted in patients with DT. When light somnolence is achieved and the patient is relaxed, management may be shifted to oral/injectable symptom monitored schedule. Vitals monitoring is extremely important and should be done regularly.
Assessments
- Patients with a history of delirium tremens and withdrawal seizures are at high risk of recurrence if they return to drinking and stop again.
- Alcohol withdrawal (alcohol withdrawal syndrome) is a range of symptoms that can happen if you stop or significantly reduce alcohol intake after long-term use.
- These mild signs include tremors, anxiety, sweating, nausea, and headaches and usually indicate the start of the withdrawal process.
- This period can involve severe tremors, confusion, hallucinations, or even seizures in extreme cases.
- However, ongoing care might be necessary for weeks if post-acute symptoms persist or complications arise.
- If you consistently consume significant amounts of alcohol, your CNS gets used to this effect.
If you’re prescribed a medication from this class of drugs talk with your doctor about the risks before taking them and always follow the doctor’s instructions. If your home environment is not supportive for staying sober, talk with your doctor. Your doctor may be able to connect you with shelter programs for people recovering from alcohol addiction. If you drink daily, your body becomes dependent on alcohol over time.
Medications for Withdrawal
Delirium tremens, or DTs, is the most severe Alcohol Withdrawal form of alcohol withdrawal. DTs typically begins between 48 and 96 hours after the last drink, though it can sometimes appear as late as seven to ten days into withdrawal. These early symptoms happen because your nervous system is starting to rebound from alcohol’s depressant effects. If you’re in a medical detox program, healthcare providers will monitor you closely and can provide medications to ease these symptoms. Given the potential severity of alcohol withdrawal symptoms, attempting to detox on your own — sometimes called “going cold turkey” — can be dangerous and, in some cases, fatal.

